What is a defining feature of substances listed under Schedule I regarding their medical application?

Substances categorized under Schedule I are defined by the fact that they are not accepted for medical use in the United States. This classification reflects a recognition that these substances lack accepted safety for use under medical supervision and have a high potential for abuse. Schedule I drugs are often associated with severe psychological or physical dependence, further discouraging any legitimate medical application.

The classification emphasizes the strict controls surrounding these substances, as they are considered to have no accepted therapeutic benefit, making them distinct from other schedules that include drugs with recognized medicinal applications. This framework is designed to prioritize public health and safety by limiting access to substances deemed highly dangerous and unqualified for clinical use.